8QN7

Amyloid-beta 40 type 1 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy

Summary for 8QN7

Entry DOI	10.2210/pdb8qn7/pdb
EMDB information	18509
Descriptor	Amyloid-beta A4 protein (1 entity in total)
Functional Keywords	amyloid-beta, amyloid, filaments, abeta40, human brain, cryo-em, alzheimer's disease, cerebral amyloid angiopathy, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	4335.85
Authors	Yang, Y.,Murzin, A.S.,Peak-Chew, S.Y.,Franco, C.,Newell, K.L.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. (deposition date: 2023-09-25, release date: 2023-12-13, Last modification date: 2024-01-31)
Primary citation	Yang, Y.,Murzin, A.G.,Peak-Chew, S.,Franco, C.,Garringer, H.J.,Newell, K.L.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11:191-191, 2023 Cited by PubMed: 38049918 DOI: 10.1186/s40478-023-01694-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation