8BG9

Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta

Summary for 8BG9

Entry DOI	10.2210/pdb8bg9/pdb
EMDB information	16027
Descriptor	Amyloid-beta protein 40 (1 entity in total)
Functional Keywords	amyloid, amyloid-beta, arctic mutation, app, nl-g-f, mouse brains, filaments, e22g, e693g, protein fibril
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	8161.08
Authors	Yang, Y.,Zhang, W.J.,Murzin, A.G.,Schweighauser, M.,Huang, M.,Lovestam, S.K.A.,Peak-Chew, S.Y.,Macdonald, J.,Lavenir, I.,Ghetti, B.,Graff, C.,Kumar, A.,Nordber, A.,Goedert, M.,Scheres, S.H.W. (deposition date: 2022-10-27, release date: 2023-01-18, Last modification date: 2024-07-24)
Primary citation	Yang, Y.,Zhang, W.,Murzin, A.G.,Schweighauser, M.,Huang, M.,Lovestam, S.,Peak-Chew, S.Y.,Saito, T.,Saido, T.C.,Macdonald, J.,Lavenir, I.,Ghetti, B.,Graff, C.,Kumar, A.,Nordberg, A.,Goedert, M.,Scheres, S.H.W. Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145:325-333, 2023 Cited by PubMed: 36611124 DOI: 10.1007/s00401-022-02533-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation