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8Y94
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BU of 8y94 by Molmil
Structure of Apo human norepinephrine transporter NET
Descriptor: Sodium-dependent noradrenaline transporter
Authors:Zhang, H, Xu, H.E, Jiang, Y.
Deposit date:2024-02-06
Release date:2024-05-29
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Dimerization and antidepressant recognition at noradrenaline transporter.
Nature, 630, 2024
8Y95
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BU of 8y95 by Molmil
Structure of NET-NE in Occluded state
Descriptor: CHLORIDE ION, Noradrenaline, SODIUM ION, ...
Authors:Zhang, H, Xu, H.E, Jiang, Y.
Deposit date:2024-02-06
Release date:2024-05-29
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Dimerization and antidepressant recognition at noradrenaline transporter.
Nature, 630, 2024
8ZJE
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BU of 8zje by Molmil
Cryo-EM structure of kisspeptin receptor bound to TAK-448
Descriptor: ACE-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Shen, S, Liu, H, Xu, H.E.
Deposit date:2024-05-14
Release date:2024-07-03
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.
Cell Rep, 43, 2024
8J6I
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BU of 8j6i by Molmil
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X.
Deposit date:2023-04-26
Release date:2024-04-03
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.
Cell Rep, 42, 2023
8J6L
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BU of 8j6l by Molmil
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X.
Deposit date:2023-04-26
Release date:2024-04-03
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.
Cell Rep, 42, 2023
8JR9
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BU of 8jr9 by Molmil
Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha-1, ...
Authors:Zhao, L, He, Q, Yuan, Q, Gu, Y, He, X, Shan, H, Li, J, Wang, K, Li, Y, Hu, W, Wu, K, Shen, J, Xu, H.E.
Deposit date:2023-06-16
Release date:2023-08-02
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Conserved class B GPCR activation by a biased intracellular agonist.
Nature, 621, 2023
8J6J
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BU of 8j6j by Molmil
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073
Descriptor: 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X.
Deposit date:2023-04-26
Release date:2024-01-10
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.
Cell Rep, 42, 2023
8YW5
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BU of 8yw5 by Molmil
Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex
Descriptor: Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W.
Deposit date:2024-03-29
Release date:2024-08-07
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Cell Discov, 10, 2024
8YW3
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BU of 8yw3 by Molmil
Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W.
Deposit date:2024-03-29
Release date:2024-09-18
Last modified:2024-09-25
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Cell Discov, 10, 2024
7F16
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BU of 7f16 by Molmil
Cryo-EM structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and G protein
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, X, Cheng, X, Zhao, L.H, Wang, Y, Ye, C, Zou, X, Dai, A, Cong, Z, Chen, J, Zhou, Q, Xia, T, Jiang, H, Xu, H.E, Yang, D, Wang, M.W.
Deposit date:2021-06-08
Release date:2021-08-18
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2.
Proc.Natl.Acad.Sci.USA, 118, 2021
7EZH
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BU of 7ezh by Molmil
Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex
Descriptor: Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y.
Deposit date:2021-06-01
Release date:2021-08-25
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Nat.Chem.Biol., 17, 2021
7EZK
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BU of 7ezk by Molmil
Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex
Descriptor: Chimera of Guanine nucleotide-binding protein G(i) subunit alpha-1 and Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y.
Deposit date:2021-06-01
Release date:2021-08-25
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Nat.Chem.Biol., 17, 2021
7EZM
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BU of 7ezm by Molmil
Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex
Descriptor: Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y.
Deposit date:2021-06-01
Release date:2021-08-25
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Nat.Chem.Biol., 17, 2021
7F4H
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BU of 7f4h by Molmil
Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16
Descriptor: Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
Cell Res., 31, 2021
7F4I
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BU of 7f4i by Molmil
Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
Cell Res., 31, 2021
7F4D
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BU of 7f4d by Molmil
Cryo-EM structure of alpha-MSH-bound melanocortin-1 receptor in complex with Gs protein and Nb35
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
Cell Res., 31, 2021
7F4F
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BU of 7f4f by Molmil
Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16
Descriptor: Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
Cell Res., 31, 2021
7EPT
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BU of 7ept by Molmil
Structural basis for the tethered peptide activation of adhesion GPCRs
Descriptor: Adhesion G-protein coupled receptor D1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Ping, Y.-Q, Xiao, P, Yang, F, Zhao, R.-J, Guo, S.-C, Yan, X, Wu, X, Liebscher, I, Xu, H.E, Sun, J.-P.
Deposit date:2021-04-27
Release date:2022-05-11
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for the tethered peptide activation of adhesion GPCRs.
Nature, 604, 2022
8YW4
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BU of 8yw4 by Molmil
Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex
Descriptor: Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W.
Deposit date:2024-03-29
Release date:2024-09-18
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Cell Discov, 10, 2024
7D68
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BU of 7d68 by Molmil
Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex
Descriptor: Glucagon-like peptide 2 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Sun, W, Chen, L, Zhou, Q, Zhao, L, Zhang, H, Cong, Z, Shen, D, Zhao, F, Zhou, F, Cai, X, Chen, Y, Zhou, Y, Gadgaard, S, van der Velden, W.J, Zhao, S, Jiang, Y, Rosenkilde, M.M, Yang, D, Xu, H.E, Zhang, Y, Wang, M.
Deposit date:2020-09-29
Release date:2020-12-16
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3 Å)
Cite:A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
Cell Res., 30, 2020
8ZPT
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BU of 8zpt by Molmil
Cryo-EM structure of prolactin-releasing peptide recognition with Gq
Descriptor: Guanine nucleotide-binding protein G(324) subunit alpha-1,, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, L, Li, Y, Yuan, Q, Xu, H.E.
Deposit date:2024-05-31
Release date:2024-09-25
Last modified:2025-07-16
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor.
Cell Discov, 10, 2024
8ZPS
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BU of 8zps by Molmil
Cryo-EM structure of prolactin-releasing peptide recognition with Gi
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha-1, ...
Authors:Zhao, L, Li, Y, Yuan, Q, Xu, H.E.
Deposit date:2024-05-31
Release date:2024-09-25
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor.
Cell Discov, 10, 2024
8ZYU
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BU of 8zyu by Molmil
Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 1)
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ...
Authors:Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C.
Deposit date:2024-06-18
Release date:2025-04-16
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator.
Cell Res., 35, 2025
8ZYT
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BU of 8zyt by Molmil
Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 3)
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ...
Authors:Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C.
Deposit date:2024-06-18
Release date:2025-04-09
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator.
Cell Res., 35, 2025
8ZYY
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BU of 8zyy by Molmil
Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 2)
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ...
Authors:Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C.
Deposit date:2024-06-18
Release date:2025-04-09
Last modified:2025-07-16
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator.
Cell Res., 35, 2025

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