8YW4

Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex

Summary for 8YW4

Entry DOI	10.2210/pdb8yw4/pdb
EMDB information	39622
Descriptor	Mini-Gs, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	g protein-coupled receptor, ligand recognition, receptor activation, unimolecular agonist, retatrutide, structural protein
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	170814.92
Authors	Li, W.Z.,Zhou, Q.T.,Cong, Z.T.,Yuan, Q.N.,Li, W.X.,Zhao, F.H.,Xu, H.E.,Zhao, L.H.,Yang, D.H.,Wang, M.W. (deposition date: 2024-03-29, release date: 2024-09-18, Last modification date: 2024-09-25)
Primary citation	Li, W.,Zhou, Q.,Cong, Z.,Yuan, Q.,Li, W.,Zhao, F.,Xu, H.E.,Zhao, L.H.,Yang, D.,Wang, M.W. Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10:77-77, 2024 Cited by PubMed: 39019866 DOI: 10.1038/s41421-024-00700-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.26 Å)

Structure validation