7D68

Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex

Summary for 7D68

• Entry DOI: 10.2210/pdb7d68/pdb
• EMDB information: 30590
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: glucagon-like peptide-2 receptor, drug target, class b gpcr, biosynthetic protein
• Biological source: Bos taurus; More
• Total number of polymer chains: 6
• Total formula weight: 185001.18

Authors

Sun, W.,Chen, L.,Zhou, Q.,Zhao, L.,Zhang, H.,Cong, Z.,Shen, D.,Zhao, F.,Zhou, F.,Cai, X.,Chen, Y.,Zhou, Y.,Gadgaard, S.,van der Velden, W.J.,Zhao, S.,Jiang, Y.,Rosenkilde, M.M.,Yang, D.,Xu, H.E.,Zhang, Y.,Wang, M. (deposition date: 2020-09-29, release date: 2020-12-16)

• Primary citation: Sun, W.,Chen, L.N.,Zhou, Q.,Zhao, L.H.,Yang, D.,Zhang, H.,Cong, Z.,Shen, D.D.,Zhao, F.,Zhou, F.,Cai, X.,Chen, Y.,Zhou, Y.,Gadgaard, S.,van der Velden, W.J.C.,Zhao, S.,Jiang, Y.,Rosenkilde, M.M.,Xu, H.E.,Zhang, Y.,Wang, M.W.; A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.; Cell Res., 30:1098-1108, 2020; PubMed: 33239759; DOI: 10.1038/s41422-020-00442-0

Experimental method

ELECTRON MICROSCOPY (3 Å)