7D68
Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 378 | 43897.8 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63097) UniProt (by SIFTS) (P04896) | Bos taurus | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40227.0 | 1 | UniProt (P62871) Pfam (PF00400) | Bos taurus (Bovine) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (Bovine) | G gamma-I |
| 4 | D (N) | Nanobody-35 | polymer | 126 | 13711.3 | 1 | synthetic construct | ||
| 5 | E (P) | Pro-glucagon | polymer | 33 | 3769.1 | 1 | UniProt (P01275) Pfam (PF00123) | Homo sapiens (Human) | |
| 6 | F (R) | Glucagon-like peptide 2 receptor | polymer | 664 | 75534.8 | 1 | Pfam (PF02793) Pfam (PF00002) UniProt (by SIFTS) (O95838) | Homo sapiens (Human) | |
| 7 | G, H (A, R) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
B: 2 - 340 (UniProt: P62871)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 185001.2 | |
| All* | Total formula weight | 185001.2 |
