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7D68

Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
P0005179molecular_functionhormone activity
P0005576cellular_componentextracellular region
R0004888molecular_functiontransmembrane signaling receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00260
Number of Residues23
DetailsGLUCAGON Glucagon / GIP / secretin / VIP family signature. HADGSFsDEMntildnlaARDFI
ChainResidueDetails
PHIS1-ILE23

site_idPS00649
Number of Residues24
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CngtFDqyv.CWphSspgnvsvp.CP
ChainResidueDetails
RCYS96-PRO119

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
BVAL327-GLY341

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues225
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
RMET1-ALA173
RTYR236-ARG261
RARG322-ILE339
RASP406-ARG417

site_idSWS_FT_FI2
Number of Residues24
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250
ChainResidueDetails
RLEU174-THR198

site_idSWS_FT_FI3
Number of Residues47
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
RLEU199-ARG210
RHIS286-LEU299
RLYS363-SER386

site_idSWS_FT_FI4
Number of Residues24
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250
ChainResidueDetails
RASN211-PHE235

site_idSWS_FT_FI5
Number of Residues23
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250
ChainResidueDetails
RSER262-LEU285
ALEU198
ATHR204

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250
ChainResidueDetails
RTRP300-ALA321

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250
ChainResidueDetails
RTRP340-LEU362

site_idSWS_FT_FI8
Number of Residues18
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250
ChainResidueDetails
RTHR387-THR405

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250
ChainResidueDetails
RLEU418-PHE438

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN97
RASN113
RASN148
RASN162

227111

PDB entries from 2024-11-06

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