4AFJ

5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors

4AFJ の概要

• エントリーDOI: 10.2210/pdb4afj/pdb
• 関連するPDBエントリー: 1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2UW9 2X37 2X39 2XH5 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH
• 分子名称: GLYCOGEN SYNTHASE KINASE-3 BETA, PROTO-ONCOGENE FRAT1, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: transferase-peptide complex, kinase, transferase/peptide
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92207.25

構造登録者

Gentile, G.,Merlo, G.,Pozzan, A.,Bernasconi, G.,Bax, B.,Bamborough, P.,Bridges, A.,Carter, P.,Neu, M.,Yao, G.,Brough, C.,Cutler, G.,Coffin, A.,Belyanskaya, S. (登録日: 2012-01-19, 公開日: 2012-02-29, 最終更新日: 2024-10-16)

主引用文献

Gentile, G.,Merlo, G.,Pozzan, A.,Bernasconi, G.,Bax, B.,Bamborough, P.,Bridges, A.,Carter, P.,Neu, M.,Yao, G.,Brough, C.,Cutler, G.,Coffin, A.,Belyanskaya, S.
5-Aryl-4-Carboxamide-1,3-Oxazoles: Potent and Selective Gsk-3 Inhibitors.
Bioorg.Med.Chem.Lett., 22:1989-, 2012

PubMed Abstract: 5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described.

PubMed: 22310227
DOI: 10.1016/J.BMCL.2012.01.034

実験手法

X-RAY DIFFRACTION (1.98 Å)