2YHD

Human androgen receptor in complex with AF2 small molecule inhibitor

Summary for 2YHD

Entry DOI	10.2210/pdb2yhd/pdb
Related	1E3G 1GS4 1T5Z 1T63 1T65 1XJ7 1XOW 1XQ3 1Z95 2AM9 2AMA 2AMB 2AO6 2AX6 2AX7 2AX8 2AX9 2AXA
Descriptor	ANDROGEN RECEPTOR, SULFATE ION, TESTOSTERONE, ... (5 entities in total)
Functional Keywords	transcription, activation function 2 site (af2), small molecule inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: P10275
Total number of polymer chains	1
Total formula weight	29708.87
Authors	AxerioCilies, P.,Lack, N.A.,ShashiNayana, M.R.,Chan, K.H.,Yeung, A.,LeBlanc, E.,Guns, E.,Rennie, P.,Cherkasov, A. (deposition date: 2011-04-28, release date: 2011-09-21, Last modification date: 2023-12-20)
Primary citation	Axerio-Cilies, P.,Lack, N.A.,Nayana, M.R.,Chan, K.H.,Yeung, A.,Leblanc, E.,Guns, E.S.,Rennie, P.S.,Cherkasov, A. Inhibitors of Androgen Receptor Activation Function-2 (Af2) Site Identified Through Virtual Screening. J.Med.Chem., 54:6197-, 2011 Cited by PubMed: 21846139 DOI: 10.1021/JM200532B PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation