1E3G

Human Androgen Receptor Ligand Binding in complex with the ligand metribolone (R1881)

Summary for 1E3G

Related1A28
DescriptorANDROGEN RECEPTOR, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE (3 entities in total)
Functional Keywordsandrogen receptor, human androgen receptor, ligand binding domain
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight30949.26
Authors
Matias, P.M.,Donner, P.,Coelho, R.,Thomaz, M.,Peixoto, C.,Macedo, S.,Otto, N.,Joschko, S.,Scholz, P.,Wegg, A.,Basler, S.,Schafer, M.,Ruff, M.,Egner, U.,Carrondo, M.A. (deposition date: 2000-06-14, release date: 2001-06-14, Last modification date: 2019-05-08)
Primary citation
Matias, P.M.,Donner, P.,Coelho, R.,Thomaz, M.,Peixoto, C.,Macedo, S.,Otto, N.,Joschko, S.,Scholz, P.,Wegg, A.,Basler, S.,Schafer, M.,Egner, U.,Carrondo, M.A.
Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.
J. Biol. Chem., 275:26164-26171, 2000
PubMed: 10840043 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M004571200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers19 1.2% 7.9% 4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution