2AO6

Crystal structure of the human androgen receptor ligand binding domain bound with TIF2(iii) 740-753 peptide and R1881

Replaces:  1XQ2

Summary for 2AO6

• Entry DOI: 10.2210/pdb2ao6/pdb
• Related: 1XOW 1XQ3
• Descriptor: androgen receptor, 14-mer fragment of Nuclear receptor coactivator 2, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE, ... (4 entities in total)
• Functional Keywords: crystal structure; human androgen receptor ligand binding domain; transcriptional intermediary factor 2 740-753; r188, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P10275 Q15596
• Total number of polymer chains: 2
• Total formula weight: 32140.68

Authors

He, B.,Gampe Jr., R.T.,Kole, A.J.,Hnat, A.T.,Stanley, T.B.,An, G.,Stewart, E.L.,Kalman, R.I.,Minges, J.T.,Wilson, E.M. (deposition date: 2005-08-12, release date: 2005-08-30, Last modification date: 2023-08-23)

• Primary citation: He, B.,Gampe Jr., R.T.,Kole, A.J.,Hnat, A.T.,Stanley, T.B.,An, G.,Stewart, E.L.,Kalman, R.I.,Minges, J.T.,Wilson, E.M.; Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance; Mol.Cell, 16:425-438, 2004; PubMed: 15525515; DOI: 10.1016/j.molcel.2004.09.036

Experimental method

X-RAY DIFFRACTION (1.89 Å)