2XHI
Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase
Summary for 2XHI
Entry DOI | 10.2210/pdb2xhi/pdb |
Related | 1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ |
Descriptor | N-GLYCOSYLASE/DNA LYASE, 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', ... (5 entities in total) |
Functional Keywords | lyase-dna complex, separation-of-function mutant, helix-hairpin-helix, dna repair, lyase/dna |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus, nucleoplasm. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion: O15527 |
Total number of polymer chains | 3 |
Total formula weight | 49843.08 |
Authors | Dalhus, B.,Forsbring, M.,Helle, I.H.,Backe, P.H.,Forstrom, R.J.,Alseth, I.,Bjoras, M. (deposition date: 2010-06-16, release date: 2011-01-26, Last modification date: 2023-12-20) |
Primary citation | Dalhus, B.,Forsbring, M.,Helle, I.H.,Vik, E.S.,Forstrom, R.J.,Backe, P.H.,Alseth, I.,Bjoras, M. Separation-of-Function Mutants Unravel the Dual- Reaction Mode of Human 8-Oxoguanine DNA Glycosylase. Structure, 19:117-, 2011 Cited by PubMed: 21220122DOI: 10.1016/J.STR.2010.09.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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