Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine

Summary for 1LWV

Related1EBM 1FN7 1HU0 1lww 1lwy
Descriptor5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE, ... (6 entities in total)
Functional Keywordsdna repair, dna glycosylase, protein/dna, borohydride, covalent trapping, product-assisted catalysis, reaction intermediate, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion O15527
Total number of polymer chains3
Total molecular weight45634.26
Fromme, J.C.,Bruner, S.D.,Yang, W.,Karplus, M.,Verdine, G.L. (deposition date: 2002-06-03, release date: 2003-02-25, Last modification date: 2011-07-13)
Primary citation
Fromme, J.C.,Bruner, S.D.,Yang, W.,Karplus, M.,Verdine, G.L.
Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10:204-211, 2003
PubMed: 12592398 (PDB entries with the same primary citation)
DOI: 10.1038/nsb902
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26216 0.3% 6.1% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-14