1HU0

CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX

Summary for 1HU0

Related1EBM 1FN7
Descriptor5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE 1, ... (6 entities in total)
Functional Keywordsdna repair, dna glycosylase, protein/dna, borohydride, covalent trapping, product-assisted catalysis, reaction intermediate, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion O15527
Total number of polymer chains3
Total molecular weight45633.23
Authors
Fromme, J.C.,Bruner, S.D.,Yang, W.,Karplus, M.,Verdine, G.L. (deposition date: 2001-01-03, release date: 2003-02-25, Last modification date: 2011-07-13)
Primary citation
Fromme, J.C.,Bruner, S.D.,Yang, W.,Karplus, M.,Verdine, G.L.
Product-Assisted Catalysis in base-excision DNA Repair
Nat.Struct.Biol., 10:204-211, 2003
PubMed: 12592398 (PDB entries with the same primary citation)
DOI: 10.1038/nsb902
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers 0.27815 0.3% 6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-09-23