2XHI

Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase

Summary for 2XHI

• Entry DOI: 10.2210/pdb2xhi/pdb
• Related: 1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ
• Descriptor: N-GLYCOSYLASE/DNA LYASE, 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', ... (5 entities in total)
• Functional Keywords: lyase-dna complex, separation-of-function mutant, helix-hairpin-helix, dna repair, lyase/dna
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus, nucleoplasm. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion: O15527
• Total number of polymer chains: 3
• Total formula weight: 49843.08

Authors

Dalhus, B.,Forsbring, M.,Helle, I.H.,Backe, P.H.,Forstrom, R.J.,Alseth, I.,Bjoras, M. (deposition date: 2010-06-16, release date: 2011-01-26, Last modification date: 2023-12-20)

• Primary citation: Dalhus, B.,Forsbring, M.,Helle, I.H.,Vik, E.S.,Forstrom, R.J.,Backe, P.H.,Alseth, I.,Bjoras, M.; Separation-of-Function Mutants Unravel the Dual- Reaction Mode of Human 8-Oxoguanine DNA Glycosylase.; Structure, 19:117-, 2011; PubMed: 21220122; DOI: 10.1016/J.STR.2010.09.023

Experimental method

X-RAY DIFFRACTION (1.55 Å)