1FN7

COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN

Summary for 1FN7

• Entry DOI: 10.2210/pdb1fn7/pdb
• Related: 1EBM
• Descriptor: DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), 8-OXOGUANINE DNA GLYCOSYLASE 1, ... (5 entities in total)
• Functional Keywords: dna repair, dna glycosylase, protein/dna, helix hairpin helix, base recognition, oxoguanine, hydroxyguanine, base flipping, flipped-out base, extrahelical dna, mechanism-based inhibitor, base-exicision repair, ap lyase, dna glycosidase, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion: O15527
• Total number of polymer chains: 3
• Total formula weight: 44720.23

Authors

Norman, D.P.G.,Bruner, S.D.,Verdine, G.L. (deposition date: 2000-08-21, release date: 2001-04-21, Last modification date: 2024-02-07)

• Primary citation: Norman, D.P.,Bruner, S.D.,Verdine, G.L.; Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.; J.Am.Chem.Soc., 123:359-360, 2001; PubMed: 11456534; DOI: 10.1021/ja003144m

Experimental method

X-RAY DIFFRACTION (2.6 Å)