2V4R

Non-productive complex of the Y-family DNA polymerase Dpo4 with dGTP skipping the M1dG adduct to pair with the next template cytosine

Summary for 2V4R

• Entry DOI: 10.2210/pdb2v4r/pdb
• Related: 1JX4 1JXL 1N48 1N56 1RYR 1RYS 1S0M 1S0N 1S0O 1S10 1S97 1S9F 2AGO 2AGP 2AGQ 2ASD 2ASJ 2ASL 2ATL 2AU0 2BQ3 2BQR 2BQU 2BR0 2C22 2C28 2C2D 2C2E 2C2R 2J6S 2J6T 2J6U 2JEF 2JEG 2JEI 2JEJ 2UVR 2UVU 2UVV 2UVW 2V4Q 2V4S 2V4T 2V9W 2VA2 2VA3
• Descriptor: DNA POLYMERASE IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3', 5'-D(*TP*CP*AP*CP*M1GP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... (6 entities in total)
• Functional Keywords: dna-directed dna polymerase, dna-binding, metal-binding, dna replication, mutator protein, nucleotidyltransferase, dna adduct, dna damage, dna repair, transferase, dpo4, m1dg, cytoplasm, magnesium
• Biological source: SULFOLOBUS SOLFATARICUS; More
• Total number of polymer chains: 3
• Total formula weight: 51219.35

Authors

Eoff, R.L.,Stafford, J.B.,Szekely, J.,Rizzo, C.J.,Egli, M.,Guengerich, F.P.,Marnett, L.J. (deposition date: 2008-09-26, release date: 2009-06-16, Last modification date: 2023-12-13)

• Primary citation: Eoff, R.L.,Stafford, J.B.,Szekely, J.,Rizzo, C.J.,Egli, M.,Guengerich, F.P.,Marnett, L.J.; Structural and Functional Analysis of Sulfolobus Solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde-Deoxyguanosine Adduct.; Biochemistry, 48:7079-, 2009; PubMed: 19492857; DOI: 10.1021/BI9003588

Experimental method

X-RAY DIFFRACTION (2.5 Å)