2UXA
Crystal structure of the GluR2-flip ligand binding domain, r/g unedited.
Summary for 2UXA
| Entry DOI | 10.2210/pdb2uxa/pdb |
| Related | 1FTJ 1FTK 1FTL 1FTM 1FTO 1FW0 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7 1MQD 1MQG 1MQH 1MQI 1MQJ 1MS7 1MXU 1MXV 1MXW 1MXX 1MXY 1MXZ 1MY0 1MY1 1MY2 1MY3 1MY4 1N0T 1NNK 1NNP 1P1N 1P1O 1P1Q 1P1U 1P1W 1SYH 1SYI 1WVJ 1XHY 2AIX 2AL4 2AL5 2ANJ 2CMO 2I3V 2I3W |
| Descriptor | GLUTAMATE RECEPTOR SUBUNIT GLUR2-FLIP, GLUTAMIC ACID, ZINC ION, ... (4 entities in total) |
| Functional Keywords | alternative splicing, postsynaptic membrane, ionic channel, ion transport, transmembrane, ampa, glur2, membrane, receptor, palmitate, ligand binding domain, membrane protein, phosphorylation, glutamate receptor, transport, rna editing, lipoprotein, glycoprotein |
| Biological source | RATTUS NORVEGICUS (RAT) |
| Total number of polymer chains | 3 |
| Total formula weight | 88391.61 |
| Authors | Greger, I.H.,Akamine, P.,Khatri, L.,Ziff, E.B. (deposition date: 2007-03-27, release date: 2007-04-10, Last modification date: 2024-11-13) |
| Primary citation | Greger, I.H.,Akamine, P.,Khatri, L.,Ziff, E.B. Developmentally Regulated, Combinatorial RNA Processing Modulates Ampa Receptor Biogenesis. Neuron, 51:85-, 2006 Cited by PubMed Abstract: The subunit composition determines AMPA receptor (AMPA-R) function and trafficking. Mechanisms underlying channel assembly are thus central to the efficacy and plasticity of glutamatergic synapses. We previously showed that RNA editing at the Q/R site of the GluR2 subunit contributes to the assembly of AMPA-R heteromers by attenuating formation of GluR2 homotetramers. Here we report that this function of the Q/R site depends on subunit contacts between adjacent ligand binding domains (LBDs). Changes of LBD interface contacts alter GluR2 assembly properties, forward traffic, and expression at synapses. Interestingly, developmentally regulated RNA editing within the LBD (at the R/G site) produces analogous effects. Our data reveal that editing to glycine reduces the self-assembly competence of this critical subunit and slows GluR2 maturation in the endoplasmic reticulum (ER). Therefore, RNA editing sites, located at strategic subunit interfaces, shape AMPA-R assembly and trafficking in a developmentally regulated manner. PubMed: 16815334DOI: 10.1016/J.NEURON.2006.05.020 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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