2UXA

Crystal structure of the GluR2-flip ligand binding domain, r/g unedited.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1263

Chain	Residue
A	GLU42
A	HIS46
A	HOH2123
B	GLU166

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B1262

Chain	Residue
B	HIS23
B	GLU30
C	HIS23
C	GLU24

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C1263

Chain	Residue
C	ASP65
C	HOH2133
C	HOH2134
A	HIS23

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B1263

Chain	Residue
A	GLU166
B	GLU42
B	HIS46
B	LEU241

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C1264

Chain	Residue
C	GLU42
C	LYS45
C	HIS46

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A1264

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	GLU193
A	HOH2061
A	HOH2081
A	HOH2126

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU C1265

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLY141
C	SER142
C	THR143
C	GLU193
C	HOH2062
C	HOH2085
C	HOH2135

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B1264

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH2114
B	HOH2154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	TRANSMEM: Helical

Chain	Residue	Details
A	ALA134-VAL154
A	ASP207-GLY227
B	ALA134-VAL154
B	ASP207-GLY227
C	ALA134-VAL154
C	ASP207-GLY227

---

site_id	SWS_FT_FI2
Number of Residues	93
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
A	PHE155-VAL181
A	GLU201-CYS206
B	PHE155-VAL181
B	GLU201-CYS206
C	PHE155-VAL181
C	GLU201-CYS206

---

site_id	SWS_FT_FI3
Number of Residues	45
Details	INTRAMEM: Helical; Pore-forming

Chain	Residue	Details
A	ARG182-ASN197
B	ARG182-ASN197
C	ARG182-ASN197

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	INTRAMEM:

Chain	Residue	Details
A	GLU198-ILE200
B	GLU198-ILE200
C	GLU198-ILE200

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
A	ILE200
B	ILE200
C	ILE200

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

---