1SYI

X-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 2.1 A RESOLUTION.

Summary for 1SYI

• Entry DOI: 10.2210/pdb1syi/pdb
• Related: 1SYH 1ftj 1ftm 1fw0 1gr2 1m5b 1m5c 1m5e 1mqd 1mqg 1nnp
• Descriptor: Glutamate receptor 2, (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID (3 entities in total)
• Functional Keywords: ionotropic glutamate receptor glur2, ligand-binding core, agonist complex, mutant, membrane protein
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 2
• Total formula weight: 58889.82

Authors

Frandsen, A.,Pickering, D.S.,Vestergaard, B.,Kasper, C.,Nielsen, B.B.,Greenwood, J.R.,Campiani, G.,Gajhede, M.,Schousboe, A.,Kastrup, J.S. (deposition date: 2004-04-01, release date: 2005-03-22, Last modification date: 2023-08-23)

• Primary citation: Frandsen, A.,Pickering, D.S.,Vestergaard, B.,Kasper, C.,Nielsen, B.B.,Greenwood, J.R.,Campiani, G.,Fattorusso, C.,Gajhede, M.,Schousboe, A.,Kastrup, J.S.; Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.; Mol.Pharmacol., 67:703-713, 2005; PubMed: 15591246; DOI: 10.1124/mol.104.002931

Experimental method

X-RAY DIFFRACTION (2.1 Å)