1SYI
X-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 2.1 A RESOLUTION.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor 2 | polymer | 263 | 29205.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2 |
| 2 | C, D (A, B) | (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID | non-polymer | 239.2 | 2 | Chemie (CPW) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 372 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 260 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| Ala -1 | - | cloning artifact |
| Gly 115 | - | SEE REMARK 999 |
| Thr 116 | - | SEE REMARK 999 |
| Phe 187 | Tyr 723 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58411.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 478.5 | |
| All* | Total formula weight | 58889.8 |
