2AL4

CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614.

Summary for 2AL4

• Entry DOI: 10.2210/pdb2al4/pdb
• Related: 1LBC 1MM6 1MM7 2AL5
• Descriptor: Glutamate receptor 2, ZINC ION, (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, ... (5 entities in total)
• Functional Keywords: ionotropic glutamate receptor, glur2, ligand binding core, s1s2, quisqualate, cx614, modulator, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 6
• Total formula weight: 177860.68

Authors

Jin, R.,Clark, S.,Weeks, A.M.,Dudman, J.T.,Gouaux, E.,Partin, K.M. (deposition date: 2005-08-04, release date: 2005-10-25, Last modification date: 2023-08-23)

• Primary citation: Jin, R.,Clark, S.,Weeks, A.M.,Dudman, J.T.,Gouaux, E.,Partin, K.M.; Mechanism of positive allosteric modulators acting on AMPA receptors.; J.Neurosci., 25:9027-9036, 2005; PubMed: 16192394; DOI: 10.1523/JNEUROSCI.2567-05.2005

Experimental method

X-RAY DIFFRACTION (1.7 Å)