2AL4

CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
F	0015276	molecular_function	ligand-gated monoatomic ion channel activity
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 821

Chain	Residue
A	GLU42
A	HIS46
B	GLU166

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 822

Chain	Residue
B	HIS23
B	GLU30

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN C 823

Chain	Residue
C	ASP65

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 824

Chain	Residue
B	GLN244
B	HOH825
B	GLU42
B	HIS46
B	LEU241

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 825

Chain	Residue
C	GLU42
C	HIS46

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 826

Chain	Residue
D	GLU42
D	HIS46
E	GLU166

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN E 827

Chain	Residue
E	HIS23
E	GLU30

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN F 828

Chain	Residue
F	ASP65

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 829

Chain	Residue
E	GLU42
E	HIS46
E	LEU241
E	GLN244
E	HOH832

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN F 830

Chain	Residue
F	GLU42
F	HIS46

---

site_id	BC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE CX6 C 801

Chain	Residue
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER217
A	LYS218
A	GLY219
A	ASN242
A	HOH952
C	PRO105
C	PHE106
C	MET107
C	SER108
C	SER217
C	LYS218
C	GLY219
C	ASN242
C	HOH851
C	HOH911
C	HOH934

---

site_id	BC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE CX6 E 802

Chain	Residue
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
B	ASN242
B	HOH967
E	PRO105
E	PHE106
E	MET107
E	SER108
E	SER217
E	LYS218
E	GLY219
E	ASN242
E	HOH830
E	HOH860
E	HOH975

---

site_id	BC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE CX6 F 803

Chain	Residue
D	PRO105
D	PHE106
D	MET107
D	SER108
D	SER217
D	LYS218
D	GLY219
D	ASN242
D	HOH778
F	PRO105
F	PHE106
F	MET107
F	SER108
F	SER217
F	LYS218
F	GLY219
F	ASN242
F	HOH515
F	HOH706
F	HOH775

---

site_id	BC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS A 807

Chain	Residue
A	HOH835
A	HOH841
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	LEU192
A	GLU193
A	MET196
A	HOH822

---

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS B 808

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	LEU192
B	GLU193
B	MET196
B	HOH829
B	HOH839
B	HOH850

---

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS C 809

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	LEU192
C	GLU193
C	MET196
C	HOH829
C	HOH837
C	HOH865

---

site_id	BC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS D 810

Chain	Residue
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	LEU138
D	GLY141
D	SER142
D	THR143
D	LEU192
D	GLU193
D	MET196
D	HOH392
D	HOH428
D	HOH455

---

site_id	BC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS E 811

Chain	Residue
E	TYR61
E	PRO89
E	LEU90
E	THR91
E	ARG96
E	LEU138
E	GLY141
E	SER142
E	THR143
E	LEU192
E	GLU193
E	MET196
E	HOH836
E	HOH846
E	HOH857

---

site_id	CC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS F 812

Chain	Residue
F	TYR61
F	PRO89
F	LEU90
F	THR91
F	ARG96
F	LEU138
F	GLY141
F	SER142
F	THR143
F	LEU192
F	GLU193
F	MET196
F	HOH417
F	HOH448
F	HOH557

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---