2AL5

Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam

Summary for 2AL5

• Entry DOI: 10.2210/pdb2al5/pdb
• Related: 1LBC 1MQI 2AL4
• Descriptor: Glutamate receptor 2, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, ... (4 entities in total)
• Functional Keywords: ionotropic glutamate receptor, glur2, ligand binding core, s1s2, fluoro-willardiine, aniracetam, modulator, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 2
• Total formula weight: 59096.91

Authors

Jin, R.,Clark, S.,Weeks, A.M.,Dudman, J.T.,Gouaux, E.,Partin, K.M. (deposition date: 2005-08-04, release date: 2005-10-25, Last modification date: 2023-08-23)

• Primary citation: Jin, R.,Clark, S.,Weeks, A.M.,Dudman, J.T.,Gouaux, E.,Partin, K.M.; Mechanism of positive allosteric modulators acting on AMPA receptors.; J.Neurosci., 25:9027-9036, 2005; PubMed: 16192394; DOI: 10.1523/JNEUROSCI.2567-05.2005

Experimental method

X-RAY DIFFRACTION (1.65 Å)