1N0T

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution.

Summary for 1N0T

Entry DOI	10.2210/pdb1n0t/pdb
Related	1FTJ 1FTK 1FTL 1FTM 1FTO 1FWO 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7
Descriptor	Glutamate receptor 2, (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, SULFATE ION, ... (5 entities in total)
Functional Keywords	ionotropic glutamate receptor glur2, ligand-binding core, antagonist complex, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	4
Total formula weight	118619.03
Authors	Hogner, A.,Greenwood, J.R.,Liljefors, T.,Lunn, M.-L.,Egebjerg, J.,Larsen, I.K.,Gouaux, E.,Kastrup, J.S. (deposition date: 2002-10-15, release date: 2003-03-04, Last modification date: 2017-08-16)
Primary citation	Hogner, A.,Greenwood, J.R.,Liljefors, T.,Lunn, M.L.,Egebjerg, J.,Larsen, I.K.,Gouaux, E.,Kastrup, J.S. Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX. J.Med.Chem., 46:214-221, 2003 Cited by PubMed: 12519060 DOI: 10.1021/jm020989v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation