1LBC
Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution
Summary for 1LBC
Entry DOI | 10.2210/pdb1lbc/pdb |
Related | 1FTJ 1LB8 1LB9 1LBB |
Descriptor | Glutamine Receptor 2, ZINC ION, GLUTAMIC ACID, ... (5 entities in total) |
Functional Keywords | ampa receptor, glur2, s1s2, ligand binding core, point mutation, n775s, cyclothiazide, ctz, agonist, membrane protein |
Biological source | Rattus norvegicus (Norway rat) |
Cellular location | Cell membrane; Multi-pass membrane protein: 1LBC |
Total number of polymer chains | 3 |
Total formula weight | 89522.04 |
Authors | Sun, Y.,Olson, R.,Horning, M.,Armstrong, N.,Mayer, M.,Gouaux, E. (deposition date: 2002-04-02, release date: 2002-05-29, Last modification date: 2023-08-16) |
Primary citation | Sun, Y.,Olson, R.,Horning, M.,Armstrong, N.,Mayer, M.,Gouaux, E. Mechanism of glutamate receptor desensitization. Nature, 417:245-253, 2002 Cited by PubMed: 12015593DOI: 10.1038/417245a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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