1LB8

Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution

Summary for 1LB8

Entry DOI	10.2210/pdb1lb8/pdb
Descriptor	Glutamate receptor 2, (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (3 entities in total)
Functional Keywords	ampa receptor, glur2, s1s2, ligand-binding core, non-desensitizing, point mutation, l483y, agonist, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	2
Total formula weight	58915.73
Authors	Sun, Y.,Olson, R.,Horning, M.,Armstrong, N.,Mayer, M.,Gouaux, E. (deposition date: 2002-04-02, release date: 2002-06-05, Last modification date: 2023-08-16)
Primary citation	Sun, Y.,Olson, R.,Horning, M.,Armstrong, N.,Mayer, M.,Gouaux, E. Mechanism of glutamate receptor desensitization. Nature, 417:245-253, 2002 Cited by PubMed: 12015593 DOI: 10.1038/417245a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation