1LB8

Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glutamate receptor 2	polymer	263	29271.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GLUR-2, GLUR-B, GLUR-K2, GLUTAMATE RECEPTOR IONOTROPIC AMPA 2
2	C, D (A, B)	(S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID	non-polymer		186.2	2	Chemie (AMQ)
3	E, F (A, B)	water	water		18.0	226	Chemie (HOH)

Sequence modifications

A, B: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	cloning artifact
Ala 2	-	cloning artifact
Tyr 94	Leu 504	engineered mutation

A, B: 120 - 263 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58543.4
Non-Polymers*	Number of molecules	2
	Total formula weight	372.3
All*	Total formula weight	58915.7

*Water molecules are not included.