1LBC

Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 321

Chain	Residue
A	GLU42
A	HIS46
A	HOH404
B	GLU166

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 322

Chain	Residue
B	HIS23
B	GLU30
B	HOH432
C	HIS23

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 323

Chain	Residue
C	ASP65
A	HIS23

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 324

Chain	Residue
A	GLU166
A	HOH338
B	GLU42
B	HIS46
B	GLN244

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 325

Chain	Residue
C	GLU42
C	HIS46
C	GLN244

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU A 326

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	GLU193
A	TYR220
A	HOH348
A	HOH385
A	HOH401

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU C 327

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	GLU193
C	TYR220
C	HOH344
C	HOH372
C	HOH387

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 328

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH373
B	HOH415
B	HOH416

---

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CYZ B 329

Chain	Residue
B	ILE92
B	LYS104
B	PRO105
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
B	LEU239
B	SER242
B	LEU247
B	ASP248
B	LYS251
B	HOH365
B	HOH425
B	HOH431

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CYZ A 330

Chain	Residue
A	LYS104
A	PRO105
A	MET107
A	SER108
A	LEU239
A	SER242
A	LEU247
A	ASP248
A	LYS251
A	HOH383
A	HOH408
C	SER217
C	LYS218
C	GLY219

---

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CYZ C 331

Chain	Residue
C	SER242
C	LEU247
C	ASP248
C	LYS251
C	HOH345
C	HOH393
A	ILE92
A	SER217
A	LYS218
A	GLY219
A	HOH333
C	LYS104
C	PRO105
C	MET107
C	SER108
C	LEU239

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---