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1LBC

Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 321
ChainResidue
AGLU42
AHIS46
AHOH404
BGLU166

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 322
ChainResidue
BHIS23
BGLU30
BHOH432
CHIS23

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN C 323
ChainResidue
CASP65
AHIS23

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 324
ChainResidue
AGLU166
AHOH338
BGLU42
BHIS46
BGLN244

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN C 325
ChainResidue
CGLU42
CHIS46
CGLN244

site_idAC6
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GLU A 326
ChainResidue
ATYR61
APRO89
ALEU90
ATHR91
AARG96
ALEU138
AGLY141
ASER142
ATHR143
AGLU193
ATYR220
AHOH348
AHOH385
AHOH401

site_idAC7
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GLU C 327
ChainResidue
CTYR61
CPRO89
CLEU90
CTHR91
CARG96
CLEU138
CGLY141
CSER142
CTHR143
CGLU193
CTYR220
CHOH344
CHOH372
CHOH387

site_idAC8
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GLU B 328
ChainResidue
BTYR61
BPRO89
BLEU90
BTHR91
BARG96
BGLY141
BSER142
BTHR143
BGLU193
BTYR220
BHOH373
BHOH415
BHOH416

site_idAC9
Number of Residues16
DetailsBINDING SITE FOR RESIDUE CYZ B 329
ChainResidue
BILE92
BLYS104
BPRO105
BMET107
BSER108
BSER217
BLYS218
BGLY219
BLEU239
BSER242
BLEU247
BASP248
BLYS251
BHOH365
BHOH425
BHOH431

site_idBC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE CYZ A 330
ChainResidue
ALYS104
APRO105
AMET107
ASER108
ALEU239
ASER242
ALEU247
AASP248
ALYS251
AHOH383
AHOH408
CSER217
CLYS218
CGLY219

site_idBC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE CYZ C 331
ChainResidue
CSER242
CLEU247
CASP248
CLYS251
CHOH345
CHOH393
AILE92
ASER217
ALYS218
AGLY219
AHOH333
CLYS104
CPRO105
CMET107
CSER108
CLEU239

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues120
DetailsTRANSMEM: Helical
ChainResidueDetails
AALA134-VAL154
AASP207-GLY227
BALA134-VAL154
BASP207-GLY227
CALA134-VAL154
CASP207-GLY227

site_idSWS_FT_FI2
Number of Residues93
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
APHE155-VAL181
AGLU201-CYS206
BPHE155-VAL181
BGLU201-CYS206
CPHE155-VAL181
CGLU201-CYS206

site_idSWS_FT_FI3
Number of Residues45
DetailsINTRAMEM: Helical; Pore-forming
ChainResidueDetails
AARG182-ASN197
BARG182-ASN197
CARG182-ASN197

site_idSWS_FT_FI4
Number of Residues6
DetailsINTRAMEM:
ChainResidueDetails
AGLU198-ILE200
BGLU198-ILE200
CGLU198-ILE200

site_idSWS_FT_FI5
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
ChainResidueDetails
APRO89
CPRO89
CTHR91
CARG96
ATHR91
AARG96
BPRO89
BTHR91
BARG96

site_idSWS_FT_FI6
Number of Residues9
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
AARG64
BARG64
CARG64

site_idSWS_FT_FI7
Number of Residues3
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
AGLN244
BGLN244
CGLN244

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues3
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues3
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
AILE200
BILE200
CILE200

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN3
BASN3
CASN3

223166

PDB entries from 2024-07-31

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