1N0T

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 264

Chain	Residue
B	LYS144
B	ARG148
B	ARG163
B	HOH377
D	HIS23

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 264

Chain	Residue
C	HOH418
C	HIS23
C	LYS144
C	ARG148
C	ARG163

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 264

Chain	Residue
B	HIS23
D	LYS144
D	ARG148
D	ARG163
D	HOH424
D	HOH464

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 265

Chain	Residue
C	LEU138
C	THR174
C	AT1266
C	HOH412

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT D 265

Chain	Residue
D	THR174
D	HOH476
D	HOH477

---

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE AT1 A 264

Chain	Residue
A	GLU13
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	GLU193
A	TYR220
A	HOH271
A	HOH289
A	HOH356
A	HOH374
A	HOH385
A	HOH391
A	HOH445

---

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE AT1 B 265

Chain	Residue
B	GLU13
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	THR195
B	TYR220
B	HOH267
B	HOH294
B	HOH306
B	HOH380
B	HOH384
B	HOH446

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AT1 C 266

Chain	Residue
C	GLU13
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	SER142
C	THR143
C	GLU193
C	TYR220
C	SO4265
C	HOH270
C	HOH276
C	HOH385
C	HOH471

---

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE AT1 D 266

Chain	Residue
D	GLU13
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	LEU138
D	GLY141
D	SER142
D	THR143
D	GLU193
D	TYR220
D	HOH273
D	HOH295
D	HOH308
D	HOH335
D	HOH341
D	HOH495

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
D	PRO89
A	THR91
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
D	ARG64
D	ARG148
D	LYS240
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121
D	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150
D	SER150

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184
D	SER184

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3
D	ASN3

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