1N0T
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 264 |
| Chain | Residue |
| B | LYS144 |
| B | ARG148 |
| B | ARG163 |
| B | HOH377 |
| D | HIS23 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 264 |
| Chain | Residue |
| C | HOH418 |
| C | HIS23 |
| C | LYS144 |
| C | ARG148 |
| C | ARG163 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 264 |
| Chain | Residue |
| B | HIS23 |
| D | LYS144 |
| D | ARG148 |
| D | ARG163 |
| D | HOH424 |
| D | HOH464 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 265 |
| Chain | Residue |
| C | LEU138 |
| C | THR174 |
| C | AT1266 |
| C | HOH412 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT D 265 |
| Chain | Residue |
| D | THR174 |
| D | HOH476 |
| D | HOH477 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE AT1 A 264 |
| Chain | Residue |
| A | GLU13 |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| A | TYR220 |
| A | HOH271 |
| A | HOH289 |
| A | HOH356 |
| A | HOH374 |
| A | HOH385 |
| A | HOH391 |
| A | HOH445 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE AT1 B 265 |
| Chain | Residue |
| B | GLU13 |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| B | THR195 |
| B | TYR220 |
| B | HOH267 |
| B | HOH294 |
| B | HOH306 |
| B | HOH380 |
| B | HOH384 |
| B | HOH446 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE AT1 C 266 |
| Chain | Residue |
| C | GLU13 |
| C | TYR61 |
| C | PRO89 |
| C | LEU90 |
| C | THR91 |
| C | ARG96 |
| C | LEU138 |
| C | SER142 |
| C | THR143 |
| C | GLU193 |
| C | TYR220 |
| C | SO4265 |
| C | HOH270 |
| C | HOH276 |
| C | HOH385 |
| C | HOH471 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE AT1 D 266 |
| Chain | Residue |
| D | GLU13 |
| D | TYR61 |
| D | PRO89 |
| D | LEU90 |
| D | THR91 |
| D | ARG96 |
| D | LEU138 |
| D | GLY141 |
| D | SER142 |
| D | THR143 |
| D | GLU193 |
| D | TYR220 |
| D | HOH273 |
| D | HOH295 |
| D | HOH308 |
| D | HOH335 |
| D | HOH341 |
| D | HOH495 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
