2CMO

The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209

2CMO の概要

• エントリーDOI: 10.2210/pdb2cmo/pdb
• 関連するPDBエントリー: 1FTJ 1FTK 1FTL 1FTM 1FTO 1FW0 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7 1MQD 1MQG 1MQH 1MQI 1MQJ 1MS7 1MXU 1MXV 1MXW 1MXX 1MXY 1MXZ 1MY0 1MY1 1MY2 1MY3 1MY4 1N0T 1NNK 1NNP 1P1N 1P1O 1P1Q 1P1U 1P1W 1SYH 1SYI 1WVJ 1XHY 2AIX 2AL4 2AL5 2ANJ
• 分子名称: GLUTAMATE RECEPTOR 2, SULFATE ION, 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID, ... (5 entities in total)
• 機能のキーワード: membrane, receptor, palmitate, transport, postsynaptic membrane, glycoprotein, ionic channel, ion transport, transmembrane, alternative splicing, rna editing, lipoprotein, ion channel
• 由来する生物種: RATTUS NORVEGICUS (RAT)
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59493.33

構造登録者

Kasper, C.,Pickering, D.S.,Mirza, O.,Olsen, L.,Kristensen, A.S.,Greenwood, J.R.,Liljefors, T.,Schousboe, A.,Watjen, F.,Gajhede, M.,Sigurskjold, B.W.,Kastrup, J.S. (登録日: 2006-05-11, 公開日: 2006-06-06, 最終更新日: 2023-12-13)

• 主引用文献: Kasper, C.,Pickering, D.S.,Mirza, O.,Olsen, L.,Kristensen, A.S.,Greenwood, J.R.,Liljefors, T.,Schousboe, A.,Watjen, F.,Gajhede, M.,Sigurskjold, B.W.,Kastrup, J.S.; The Structure of a Mixed Glur2 Ligand-Binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-Ns1209.; J.Mol.Biol., 357:1184-, 2006; PubMed: 16483599; DOI: 10.1016/J.JMB.2006.01.024

実験手法

X-RAY DIFFRACTION (2.65 Å)