Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 600 |
| Chain | Residue |
| A | LYS144 |
| A | ARG148 |
| A | ARG163 |
| A | HOH2091 |
| B | HIS23 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | HOH2092 |
| A | LEU138 |
| A | SER142 |
| A | THR143 |
| A | M1L1112 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 601 |
| Chain | Residue |
| B | SER140 |
| B | LYS144 |
| B | ARG148 |
| B | HOH2136 |
| B | HOH2137 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| A | SER217 |
| B | MET107 |
| B | SER108 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLU B1111 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| B | MET196 |
| B | TYR220 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE M1L A1112 |
| Chain | Residue |
| A | GLU13 |
| A | TYR16 |
| A | TYR61 |
| A | GLY62 |
| A | ALA63 |
| A | PRO89 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | ARG172 |
| A | THR173 |
| A | THR174 |
| A | GLU193 |
| A | TYR220 |
| A | SO4602 |
| A | HOH2093 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | ALA134-VAL154 | |
| A | ASP207-GLY227 | |
| B | ALA134-VAL154 | |
| B | ASP207-GLY227 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 62 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | PHE155-VAL181 | |
| A | GLU201-CYS206 | |
| B | PHE155-VAL181 | |
| B | GLU201-CYS206 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| A | ARG182-ASN197 | |
| B | ARG182-ASN197 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | GLU198-ILE200 | |
| B | GLU198-ILE200 | |
| Chain | Residue | Details |
| A | PRO89 | |
| B | SER142 | |
| B | THR143 | |
| B | GLU193 | |
| A | THR91 | |
| A | ARG96 | |
| A | SER142 | |
| A | THR143 | |
| A | GLU193 | |
| B | PRO89 | |
| B | THR91 | |
| B | ARG96 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG64 | |
| A | ARG148 | |
| A | LYS240 | |
| B | ARG64 | |
| B | ARG148 | |
| B | LYS240 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 | |
| B | ILE121 | |
| Chain | Residue | Details |
| A | SER150 | |
| B | SER150 | |
| Chain | Residue | Details |
| A | SER184 | |
| B | SER184 | |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE200 | |
| B | ILE200 | |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 | |
| B | ASN3 | |
