2CMO

The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	GLUTAMATE RECEPTOR 2	polymer	263	29221.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	RATTUS NORVEGICUS (RAT)	GLUR2 LIGAND-BINDING CORE, S1S2J, GLUR-2, GLUR-B, GLUR-K2, GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2, AMPA-SELECTIVE GLUTAMATE RECEPTOR 2
2	A, B	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	A	2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID	non-polymer		518.6	1	Chemie (M1L)
4	B	GLUTAMIC ACID	non-polymer		147.1	1	Chemie (GLU)
5		water	water		18.0	230	Chemie (HOH)

Sequence modifications

A, B: 1 - 2 (PDB: 2CMO)
A, B: 118 - 119 (PDB: 2CMO)
A, B: 3 - 117 (UniProt: P19491)
A, B: 120 - 263 (UniProt: P19491)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58443.4
Non-Polymers*	Number of molecules	6
	Total formula weight	1050.0
All*	Total formula weight	59493.3

*Water molecules are not included.