1W82
p38 Kinase crystal structure in complex with small molecule inhibitor
Summary for 1W82
Entry DOI | 10.2210/pdb1w82/pdb |
Related | 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W83 1W84 1WFC |
Descriptor | MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[(3Z)-5-TERT-BUTYL-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-3-YLIDENE]-N'-(4-CHLOROPHENYL)UREA (3 entities in total) |
Functional Keywords | kinase/inhibitor, kinase-inhibitor complex, p38, kinase, inhibitor complex |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41712.06 |
Authors | Tickle, J.,Jhoti, H.,Cleasby, A.,Devine, L. (deposition date: 2004-09-16, release date: 2005-02-08, Last modification date: 2018-01-31) |
Primary citation | Gill, A.,Frederickson, M.,Cleasby, A.,Woodhead, S.,Carr, M.,Woodhead, A.,Walker, M.,Congreve, M.,Devine, L.,Tisi, D.,O'Reilly, M.,Seavers, L.,Davis, D.,Curry, J.,Anthony, R.,Padova, A.,Murray, C.,Carr, R.,Jhoti, H. Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation J.Med.Chem., 48:414-, 2005 Cited by PubMed: 15658855DOI: 10.1021/JM049575N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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