1LW2
CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91
Summary for 1LW2
Entry DOI | 10.2210/pdb1lw2/pdb |
Related | 1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JKH 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1JLQ 1KLM 1LW0 1LWC 1LWE 1LWF 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1VRT 1VRU |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE, ... (4 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, aids, azt, 3tc, nrti, 1051u91, drug resistance mutations, transferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116606.38 |
Authors | Ren, J.,Chamberlain, P.P.,Nichols, C.E.,Douglas, L.,Stuart, D.I.,Stammers, D.K. (deposition date: 2002-05-30, release date: 2002-10-30, Last modification date: 2021-11-10) |
Primary citation | Chamberlain, P.P.,Ren, J.,Nichols, C.E.,Douglas, L.,Lennerstrand, J.,Larder, B.A.,Stuart, D.I.,Stammers, D.K. Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215. J.Virol., 76:10015-10019, 2002 Cited by PubMed: 12208978DOI: 10.1128/JVI.76.19.10015-10019.2002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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