1IKF

A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX

1IKF の概要

• エントリーDOI: 10.2210/pdb1ikf/pdb
• 関連するPDBエントリー: 1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1M63 1MF8 1MIK 1QNG 1QNH 1XQ7 2ESL 2OJU 2POY 2RMA 2RMB 2RMC 2WFJ 2X2C 2X7K 2Z6W 3BO7 3CYS 3EOV
• 関連するBIRD辞書のPRD_ID: PRD_000142
• 分子名称: IGG1-KAPPA R45-45-11 FAB (LIGHT CHAIN), IGG1-KAPPA R45-45-11 FAB (HEAVY CHAIN), CYCLOSPORIN A, ... (4 entities in total)
• 機能のキーワード: immune system-immunosuppressant complex, fab-cyclosporin complex, cyclosporin a, immunosuppressant, immune system/immunosuppressant
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49547.51

構造登録者

Vix, O.,Altschuh, D.,Rees, B.,Thierry, J.-C. (登録日: 1993-12-09, 公開日: 1995-03-31, 最終更新日: 2024-06-05)

主引用文献

Altschuh, D.,Vix, O.,Rees, B.,Thierry, J.C.
A Conformation of Cyclosporin a in Aqueous Environment Revealed by the X-Ray Structure of a Cyclosporin-Fab Complex.
Science, 256:92-, 1992

PubMed Abstract: The conformation of the immunosuppressive drug cyclosporin A (CsA) in a complex with a Fab molecule has been established by crystallographic analysis to 2.65 angstrom resolution. This conformation of CsA is similar to that recently observed in the complex with the rotamase cyclophilin, its binding protein in vivo, and totally different from its conformation in an isolated form as determined from x-ray and nuclear magnetic resonance analysis. Because the surfaces of CsA interacting with cyclophilin or with the Fab are not identical, these results suggest that the conformation of CsA observed in the bound form preexists in aqueous solution and is not produced by interaction with the proteins.

PubMed: 1566062
DOI: 10.1126/SCIENCE.1566062

実験手法

X-RAY DIFFRACTION (2.5 Å)