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1H01

CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor

Summary for 1H01
Entry DOI10.2210/pdb1h01/pdb
Related1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H06 1H07 1H08 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1QMZ
DescriptorCYCLIN-DEPENDENT KINASE 2, GLYCEROL, (2R)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL, ... (5 entities in total)
Functional Keywordsserine/threonine-protein kinase, mitosis, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight35100.37
Authors
Breault, G.A.,Ellston, R.P.A.,Green, S.,James, S.R.,Jewsbury, P.J.,Midgley, C.J.,Minshull, C.A.,Pauptit, R.A.,Tucker, J.A.,Pease, J.E. (deposition date: 2002-06-10, release date: 2003-07-11, Last modification date: 2011-10-19)
Primary citationBeattie, J.F.,Breault, G.A.,Ellston, R.P.A.,Green, S.,Jewsbury, P.J.,Midgley, C.J.,Naven, R.T.,Minshull, C.A.,Pauptit, R.A.,Tucker, J.A.,Pease, J.E.
Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines
Bioorg.Med.Chem.Lett., 13:2955-, 2003
Cited by
PubMed: 12941311
DOI: 10.1016/S0960-894X(03)00202-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.79 Å)
Structure validation

217157

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