1CWI

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN

Summary for 1CWI

• Entry DOI: 10.2210/pdb1cwi/pdb
• Related: 1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1IKF 1M63 1MF8 1MIK 1QNG 1QNH 1XQ7 2ESL 2OJU 2POY 2RMA 2RMB 2RMC 2WFJ 2X2C 2X7K 2Z6W 3BO7 3CYS 3EOV
• Related PRD ID: PRD_001122
• Descriptor: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D (3 entities in total)
• Functional Keywords: isomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, cyclophilin, isomerase/immunosuppressant
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm : P62937
• Total number of polymer chains: 2
• Total formula weight: 19285.18

Authors

Mikol, V.,Kallen, J.,Taylor, P.,Walkinshaw, M.D. (deposition date: 1998-05-25, release date: 1998-08-12, Last modification date: 2023-08-09)

Primary citation

Kallen, J.,Mikol, V.,Taylor, P.,Walkinshaw, M.D.
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283:435-, 1998

PubMed Abstract: Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.

PubMed: 9769216
DOI: 10.1006/JMBI.1998.2108

Experimental method

X-RAY DIFFRACTION (1.9 Å)