6FK4
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STRUCTURE OF 3' PHOSPHATASE NEXO (WT) FROM NEISSERIA BOUND TO DNA SUBSTRATE
Descriptor:Exodeoxyribonuclease III, DNA (5'-D(P*GP*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Silhan, J., Zhao, Q., Boura, E., Thomson, H., Foster, A., Tang, C.M., Freemont, P.S., Baldwin, G.S.
Deposit date:2018-01-23
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.297 Å)
Cite:Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.
Nucleic Acids Res., 2018
6FK5
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STRUCTURE OF 3' PHOSPHATASE NEXO (D146N) FROM NEISSERIA BOUND TO DNA SUBSTRATE IN PRESENCE OF MAGNESIUM ION
Descriptor:NExo D146N, DNA (5'-D(P*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), MAGNESIUM ION, ...
Authors:Silhan, J., Zhao, Q., Boura, E., Thomson, H., Foster, A., Tang, C.M., Freemont, P.S., Baldwin, G.S.
Deposit date:2018-01-23
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.
Nucleic Acids Res., 2018
6FKE
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STRUCTURE OF 3' PHOSPHATASE NEXO (D146N) FROM NEISSERIA BOUND TO PRODUCT DNA HAIRPIN
Descriptor:Exodeoxyribonuclease III, DNA (5'-D(*GP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*A)-3'), (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Silhan, J., Zhao, Q., Boura, E., Thomson, H., Foster, A., Tang, C.M., Freemont, P.S., Baldwin, G.S.
Deposit date:2018-01-23
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.
Nucleic Acids Res., 2018
6MAL
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STRUCTURE OF HUMAN NOCTURNIN C-TERMINAL DOMAIN
Descriptor:Nocturnin, MAGNESIUM ION
Authors:Estrella, M.A., Du, J., Korennykh, A.
Deposit date:2018-08-28
Release date:2018-09-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Human Nocturnin Catalytic Domain
bioRxiv, 2018
6BOQ
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HUMAN APE1 SUBSTRATE COMPLEX WITH AN A/A MISMATCH ADJACENT THE THF
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 21-mer DNA, 1,2-ETHANEDIOL
Authors:Freudenthal, B.D., Whitaker, A.M., Fairlamb, M.S.
Deposit date:2017-11-20
Release date:2018-08-15
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches.
Acta Crystallogr D Struct Biol, 74, 2018
6BOR
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HUMAN APE1 SUBSTRATE COMPLEX WITH AN G/G MISMATCH ADJACENT THE THF
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 21-mer DNA, 1,2-ETHANEDIOL, ...
Authors:Freudenthal, B.D., Whitaker, A.M., Fairlamb, M.S.
Deposit date:2017-11-20
Release date:2018-08-15
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches.
Acta Crystallogr D Struct Biol, 74, 2018
6BOS
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HUMAN APE1 SUBSTRATE COMPLEX WITH AN A/C MISMATCH ADJACENT THE THF
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 21-mer DNA
Authors:Freudenthal, B.D., Whitaker, A.M., Fairlamb, M.S.
Deposit date:2017-11-20
Release date:2018-08-15
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches.
Acta Crystallogr D Struct Biol, 74, 2018
6BOT
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HUMAN APE1 SUBSTRATE COMPLEX WITH AN C/C MISMATCH ADJACENT THE THF
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 21-mer DNA, 1,2-ETHANEDIOL
Authors:Freudenthal, B.D., Whitaker, A.M., Fairlamb, M.S.
Deposit date:2017-11-20
Release date:2018-08-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches.
Acta Crystallogr D Struct Biol, 74, 2018
6BOU
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HUMAN APE1 SUBSTRATE COMPLEX WITH AN T/C MISMATCH ADJACENT THE THF
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 21-mer DNA
Authors:Freudenthal, B.D., Whitaker, A.M., Fairlamb, M.S.
Deposit date:2017-11-20
Release date:2018-08-15
Method:X-RAY DIFFRACTION (2.538 Å)
Cite:Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches.
Acta Crystallogr D Struct Biol, 74, 2018
6BOV
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HUMAN APE1 SUBSTRATE COMPLEX WITH AN A/G MISMATCH ADJACENT THE THF
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 21-mer DNA, DI(HYDROXYETHYL)ETHER
Authors:Freudenthal, B.D., Whitaker, A.M., Fairlamb, M.S.
Deposit date:2017-11-20
Release date:2018-08-15
Method:X-RAY DIFFRACTION (1.975 Å)
Cite:Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches.
Acta Crystallogr D Struct Biol, 74, 2018
6BOW
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HUMAN APE1 SUBSTRATE COMPLEX WITH AN T/T MISMATCH ADJACENT THE THF
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 21-mer DNA
Authors:Freudenthal, B.D., Whitaker, A.M., Fairlamb, M.S.
Deposit date:2017-11-20
Release date:2018-08-15
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches.
Acta Crystallogr D Struct Biol, 74, 2018
6BT1
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STRUCTURE OF THE HUMAN NOCTURNIN CATALYTIC DOMAIN
Descriptor:Nocturnin, MAGNESIUM ION
Authors:Abshire, E.T., Chasseur, J., Del Rizzo, P., Trievel, R.
Deposit date:2017-12-04
Release date:2018-05-16
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
Nucleic Acids Res., 46, 2018
6BT2
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STRUCTURE OF THE HUMAN NOCTURNIN CATALYTIC DOMAIN WITH BOUND SULFATE ANION
Descriptor:Nocturnin, MAGNESIUM ION, SULFATE ION
Authors:Abshire, E.T., Chasseur, J., Del Rizzo, P., Trievel, R.
Deposit date:2017-12-04
Release date:2018-05-16
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.411 Å)
Cite:The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
Nucleic Acids Res., 46, 2018
6CA4
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CRYSTAL STRUCTURE OF HUMANIZED D. RERIO TDP2 BY 14 MUTATIONS
Descriptor:Tyrosyl-DNA phosphodiesterase 2, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Shi, K., Aihrara, H.
Deposit date:2018-01-29
Release date:2018-05-02
Method:X-RAY DIFFRACTION (1.623 Å)
Cite:New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).
Eur J Pharm Sci, 118, 2018
5WN0
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APE1 EXONUCLEASE SUBSTRATE COMPLEX WITH A C/G MATCH
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Freudenthal, B.D., Whitaker, A.M.
Deposit date:2017-07-31
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Nat Commun, 9, 2018
5WN1
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APE1 EXONUCLEASE PRODUCT COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*G)-3'), ...
Authors:Freudenthal, B.D., Whitaker, A.M.
Deposit date:2017-07-31
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Nat Commun, 9, 2018
5WN2
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APE1 EXONUCLEASE SUBSTRATE COMPLEX WITH PHOSPHOGLYCOLATE
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*G)-3'), ...
Authors:Freudenthal, B.D., Whitaker, A.M.
Deposit date:2017-07-31
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.288 Å)
Cite:Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Nat Commun, 9, 2018
5WN3
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APE1 F266A EXONUCLEASE SUBSTRATE COMPLEX WITH A C/T MISMATCH
Descriptor:DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DV3))-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Freudenthal, B.D., Whitaker, A.M.
Deposit date:2017-07-31
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Nat Commun, 9, 2018
5WN4
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APE1 EXONUCLEASE SUBSTRATE COMPLEX WITH A C/T MISMATCH
Descriptor:DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DV3))-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Freudenthal, B.D., Whitaker, A.M.
Deposit date:2017-07-31
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Nat Commun, 9, 2018
5WN5
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APE1 EXONUCLEASE SUBSTRATE COMPLEX WITH A C/T MISMATCH AND MN2+
Descriptor:DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DV3))-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Freudenthal, B.D., Whitaker, A.M.
Deposit date:2017-07-31
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Nat Commun, 9, 2018
5TVP
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SUMO2 BOUND TO MOUSE TDP2 CATALYTIC DOMAIN WITH A 5'-PHOSPHORYLATED DNA TERNARY COMPLEX
Descriptor:Tyrosyl-DNA phosphodiesterase 2, DNA (5'-D(P*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), Small ubiquitin-related modifier 2, ...
Authors:Schellenberg, M.J., Williams, R.S.
Deposit date:2016-11-09
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.399 Å)
Cite:ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
Science, 357, 2017
5TVQ
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MOUSE TDP2 CATALYTIC DOMAIN BOUND TO SUMO2
Descriptor:Tyrosyl-DNA phosphodiesterase 2, Small ubiquitin-related modifier 2, CALCIUM ION, ...
Authors:Schellenberg, M.J., Williams, R.S.
Deposit date:2016-11-09
Release date:2017-09-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
Science, 357, 2017
5OKM
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CRYSTAL STRUCTURE OF HUMAN SHIP2 PHOSPHATASE-C2
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, NITRATE ION, ...
Authors:Le Coq, J., Lietha, D.
Deposit date:2017-07-25
Release date:2017-08-23
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.
Elife, 6, 2017
5OKN
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CRYSTAL STRUCTURE OF HUMAN SHIP2 PHOSPHATASE-C2 D607A MUTANT
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 1,2-ETHANEDIOL, ...
Authors:Le Coq, J., Lietha, D.
Deposit date:2017-07-25
Release date:2017-08-23
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.
Elife, 6, 2017
5OKO
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CRYSTAL STRUCTURE OF HUMAN SHIP2 PHOSPHATASE-C2 DOUBLE MUTANT F593D/L597D
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Le Coq, J., Lietha, D.
Deposit date:2017-07-25
Release date:2017-08-23
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.
Elife, 6, 2017
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