8SP7
LINE-1 retrotransposon endonuclease domain complex with tranexamic acid
Summary for 8SP7
| Entry DOI | 10.2210/pdb8sp7/pdb |
| Descriptor | LINE-1 retrotransposon endonuclease, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | line-1 retrotransposon, endonuclease, fragment screening, small molecule complex, hydrolase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 27504.68 |
| Authors | |
| Primary citation | D'Ordine, A.M.,Jogl, G.,Sedivy, J.M. Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease. Nat Commun, 15:3883-3883, 2024 Cited by PubMed: 38719805DOI: 10.1038/s41467-024-48066-x PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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