7TC2

Human APE1 in complex with 5-nitroindole-2-carboxylic acid

Summary for 7TC2

Entry DOI	10.2210/pdb7tc2/pdb
Descriptor	DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial, 5-nitro-1H-indole-2-carboxylic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	ap endonuclease1, ape1, inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	129456.84
Authors	Pidugu, L.S.,Pozharski, E.,Drohat, A.C. (deposition date: 2021-12-22, release date: 2022-12-21, Last modification date: 2023-10-25)
Primary citation	Pidugu, L.S.,Servius, H.W.,Sevdalis, S.E.,Cook, M.E.,Varney, K.M.,Pozharski, E.,Drohat, A.C. Characterizing inhibitors of human AP endonuclease 1. Plos One, 18:e0280526-e0280526, 2023 Cited by PubMed: 36652434 DOI: 10.1371/journal.pone.0280526 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation