9IK1
| Cryo-EM structure of the human P2X3 receptor-compound 26a complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[2-cyclopropyl-7-[[(1~{R})-1-naphthalen-2-ylethyl]amino]-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]piperazine-1-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Kim, S, Kim, G.R, Kim, Y.O, Han, X, Nagel, J, Kim, J, Song, D.I, Muller, C.E, Yoon, M.H, Jin, M.S, Kim, Y.C. | Deposit date: | 2024-06-26 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy. J.Med.Chem., 67, 2024
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8V4S
| Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-11-29 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8TRJ
| Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-(4-benzoylbenzoyl)adenosine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8TR5
| Cryo-EM structure of the rat P2X7 receptor in the apo closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8JV8
| Cryo-EM structure of the panda P2X7 receptor in complex with PPNDS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, P2X purinoceptor | Authors: | Sheng, D, Hattori, M. | Deposit date: | 2023-06-27 | Release date: | 2023-11-29 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists. Elife, 12, 2024
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8JV7
| Cryo-EM structure of the panda P2X7 receptor in complex with PPADS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(E)-[4-methanoyl-6-methyl-5-oxidanyl-3-(phosphonooxymethyl)pyridin-2-yl]diazenyl]benzene-1,3-disulfonic acid, P2X purinoceptor | Authors: | Sheng, D, Hattori, M. | Deposit date: | 2023-06-27 | Release date: | 2023-11-29 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists. Elife, 12, 2024
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8JV6
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8JV5
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6U9W
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6U9V
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6AH5
| Structure of human P2X3 receptor in complex with ATP and Mg2+ ion | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Hattori, M. | Deposit date: | 2018-08-16 | Release date: | 2019-06-12 | Last modified: | 2020-12-23 | Method: | X-RAY DIFFRACTION (3.819 Å) | Cite: | Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP. Elife, 8, 2019
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6AH4
| Structure of human P2X3 receptor in complex with ATP and Ca2+ ion | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Hattori, M. | Deposit date: | 2018-08-16 | Release date: | 2019-06-12 | Last modified: | 2020-12-23 | Method: | X-RAY DIFFRACTION (3.296 Å) | Cite: | Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP. Elife, 8, 2019
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5YVE
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5WZY
| Crystal structure of the P2X4 receptor from zebrafish in the presence of CTP at 2.8 Angstroms | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, ... | Authors: | Kasuya, G, Hattori, M, Nureki, O. | Deposit date: | 2017-01-19 | Release date: | 2017-04-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Structural insights into the nucleotide base specificity of P2X receptors Sci Rep, 7, 2017
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5U2H
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5U1Y
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5U1X
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5U1W
| Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist AZ10606120 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]-2-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]acetamide, ... | Authors: | Karasawa, A, Kawate, T. | Deposit date: | 2016-11-29 | Release date: | 2017-01-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.501 Å) | Cite: | Structural basis for subtype-specific inhibition of the P2X7 receptor. Elife, 5, 2016
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5U1V
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5U1U
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5U1L
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5SVT
| Anomalous Cs+ signal reveals the site of Na+ ion entry to the channel pore of the human P2X3 ion channel through the extracellular fenestrations | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, P2X purinoceptor 3, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.794 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVS
| Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.025 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVR
| Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist A-317491 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid, MAGNESIUM ION, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-10-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVQ
| Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, P2X purinoceptor 3, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-10-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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