5SVT

Anomalous Cs+ signal reveals the site of Na+ ion entry to the channel pore of the human P2X3 ion channel through the extracellular fenestrations

Summary for 5SVT

Entry DOI	10.2210/pdb5svt/pdb
Related	5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVR 5SVS
Descriptor	P2X purinoceptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	membrane protein, ion channel, anomalous signal
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41456.84
Authors	Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. (deposition date: 2016-08-07, release date: 2016-09-28, Last modification date: 2020-07-29)
Primary citation	Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538:66-71, 2016 Cited by PubMed: 27626375 DOI: 10.1038/nature19367 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.794 Å)

Structure validation