5SVP
Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state
Summary for 5SVP
Entry DOI | 10.2210/pdb5svp/pdb |
Related | 5SVJ 5SVK 5SVL 5SVM 5SVQ 5SVR 5SVS 5SVT |
Descriptor | P2X purinoceptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), ... (7 entities in total) |
Functional Keywords | ion channel, desensitized state, anomalous signal, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 84127.62 |
Authors | Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. (deposition date: 2016-08-07, release date: 2016-09-28, Last modification date: 2020-07-29) |
Primary citation | Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538:66-71, 2016 Cited by PubMed: 27626375DOI: 10.1038/nature19367 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.298 Å) |
Structure validation
Download full validation report