5SVP
Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | P2X purinoceptor 3 | polymer | 363 | 40723.8 | 2 | UniProt (P56373) Pfam (PF00864) | Homo sapiens (Human) | P2X3,ATP receptor,Purinergic receptor |
| 2 | C, D, E, K, L... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 3 | F (A) | 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate) | non-polymer | 553.3 | 1 | Chemie (6AT) | |||
| 4 | G, N (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | H (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | I, O (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | J (B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) |
Sequence modifications
A, B: 6 - 364 (UniProt: P56373)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Arg 4 | - | expression tag |
| Ala 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81447.7 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2680.0 | |
| All* | Total formula weight | 84127.6 |
