5SVR
Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist A-317491
Summary for 5SVR
Entry DOI | 10.2210/pdb5svr/pdb |
Related | 5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVS 5SVT |
Descriptor | P2X purinoceptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | membrane protein ion channel antagonist state, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41801.20 |
Authors | Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. (deposition date: 2016-08-07, release date: 2016-10-05, Last modification date: 2020-07-29) |
Primary citation | Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538:66-71, 2016 Cited by PubMed: 27626375DOI: 10.1038/nature19367 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.13 Å) |
Structure validation
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