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9CSI
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BU of 9csi by Molmil
A. baumannii MsbA Bound to Cerastecin Compound 5
Descriptor: 3,3'-[(1,4-dioxobutane-1,4-diyl)bis(azanediyl)]bis[(4-butylbenzene-1-sulfonamido)benzoic acid], Lipid A export ATP-binding/permease protein MsbA, MAGNESIUM ION, ...
Authors:Klein, D.J, Ishchenko, A, Soisson, S, Cheng, R, Hennig, M.
Deposit date:2024-07-23
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy.
J.Med.Chem., 2024
6VQT
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BU of 6vqt by Molmil
Structure of a bacterial Atm1-family ABC exporter with MgADPVO4 bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATM1-type heavy metal exporter, MAGNESIUM ION, ...
Authors:Fan, C, Rees, D.C.
Deposit date:2020-02-05
Release date:2020-07-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:A structural framework for unidirectional transport by a bacterial ABC exporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
6VQU
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BU of 6vqu by Molmil
Structure of a bacterial Atm1-family ABC exporter
Descriptor: ATM1-type heavy metal exporter
Authors:Fan, C, Rees, D.C.
Deposit date:2020-02-05
Release date:2020-07-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:A structural framework for unidirectional transport by a bacterial ABC exporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
7FC9
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BU of 7fc9 by Molmil
Crystal structure of CmABCB1 in lipidic mesophase revealed by LCP-SFX
Descriptor: ACETATE ION, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Pan, D, Oyama, R, Sato, T, Nakane, T, Mizunuma, R, Matsuoka, K, Joti, Y, Tono, K, Nango, E, Iwata, S, Nakatsu, T, Kato, H.
Deposit date:2021-07-14
Release date:2022-02-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX.
Iucrj, 9, 2022
4XWK
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BU of 4xwk by Molmil
P-glycoprotein co-crystallized with BDE-100
Descriptor: 2,4-dibromophenyl 2,4,6-tribromophenyl ether, Multidrug resistance protein 1A
Authors:McGrath, A.P, Rees, S.D, Chang, G.
Deposit date:2015-01-28
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure.
Sci Adv, 2, 2016
2HYD
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BU of 2hyd by Molmil
Multidrug ABC transporter SAV1866
Descriptor: ABC transporter homolog, ADENOSINE-5'-DIPHOSPHATE, SODIUM ION
Authors:Dawson, R.J.P, Locher, K.P.
Deposit date:2006-08-05
Release date:2006-09-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a bacterial multidrug ABC transporter.
Nature, 443, 2006
3QF4
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BU of 3qf4 by Molmil
Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation
Descriptor: ABC transporter, ATP-binding protein, MAGNESIUM ION, ...
Authors:Hohl, M, Briand, C, Gruetter, M.G, Seeger, M.A.
Deposit date:2011-01-21
Release date:2012-03-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation
Nat.Struct.Mol.Biol., 19, 2012
2ONJ
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BU of 2onj by Molmil
Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP
Descriptor: Multidrug export ATP-binding/permease protein SAV1866, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION
Authors:Dawson, R.J.P, Locher, K.P.
Deposit date:2007-01-24
Release date:2007-03-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP.
Febs Lett., 581, 2007
4F4C
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BU of 4f4c by Molmil
The Crystal Structure of the Multi-Drug Transporter
Descriptor: Multidrug resistance protein pgp-1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, undecyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside
Authors:Jin, M.S, Oldham, M.L, Zhang, Q, Chen, J.
Deposit date:2012-05-10
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans.
Nature, 490, 2012
3G60
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BU of 3g60 by Molmil
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Descriptor: (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1a
Authors:Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
6O2P
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BU of 6o2p by Molmil
Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, ...
Authors:Liu, F, Zhang, Z, Chen, J, Levit, A, Shoichet, B.
Deposit date:2019-02-24
Release date:2019-06-26
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural identification of a hotspot on CFTR for potentiation.
Science, 364, 2019
6O30
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BU of 6o30 by Molmil
Lipid A transporter MsbA from Salmonella typhimurium
Descriptor: Lipid A export ATP-binding/permease protein MsbA
Authors:Padayatti, P.S, Zhang, Q, Wilson, I.A, Lee, S.C, Stanfield, R.L.
Deposit date:2019-02-25
Release date:2019-06-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4.47 Å)
Cite:Structural Insights into the Lipid A Transport Pathway in MsbA.
Structure, 27, 2019
3G5U
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BU of 3g5u by Molmil
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Descriptor: MERCURY (II) ION, Multidrug resistance protein 1a
Authors:Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
3G61
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BU of 3g61 by Molmil
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Descriptor: (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1a
Authors:Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (4.35 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
6O1V
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BU of 6o1v by Molmil
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ...
Authors:Zhang, Z, Liu, F, Chen, J, Levit, A, Shoichet, B.
Deposit date:2019-02-21
Release date:2019-06-26
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural identification of a hotspot on CFTR for potentiation.
Science, 364, 2019
4KSC
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BU of 4ksc by Molmil
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
Descriptor: Multidrug resistance protein 1A
Authors:Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSD
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BU of 4ksd by Molmil
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
Descriptor: Multidrug resistance protein 1A, R2 protein
Authors:Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (4.1001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSB
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BU of 4ksb by Molmil
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
Descriptor: Multidrug resistance protein 1A
Authors:Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.8001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
6JB1
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BU of 6jb1 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
Deposit date:2019-01-25
Release date:2019-05-22
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
5C73
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BU of 5c73 by Molmil
ATP-driven lipid-linked oligosaccharide flippase PglK in outward-occluded conformation
Descriptor: Protein glycosylation K
Authors:Perez, C, Locher, K.P.
Deposit date:2015-06-24
Release date:2015-08-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (5.9 Å)
Cite:Structure and mechanism of an active lipid-linked oligosaccharide flippase.
Nature, 524, 2015
6FN4
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BU of 6fn4 by Molmil
Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Apo form of Human-mouse chimeric ABCB1 (ABCB1HM) in complex with Antigen binding fragment of UIC2., ...
Authors:Alam, A, Locher, K.P.
Deposit date:2018-02-02
Release date:2018-02-21
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8CHB
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BU of 8chb by Molmil
Inward-facing conformation of the ABC transporter BmrA C436S/A582C cross-linked mutant
Descriptor: Multidrug resistance ABC transporter ATP-binding/permease protein BmrA
Authors:Di Cesare, M, Kaplan, E, Hanssen, E, Valimehr, S, Orelle, C, Jault, J.M.
Deposit date:2023-02-07
Release date:2023-12-20
Last modified:2024-01-24
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains.
J.Biol.Chem., 300, 2023
5C78
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BU of 5c78 by Molmil
ATP-driven lipid-linked oligosaccharide flippase PglK in apo-inward state (1)
Descriptor: ATP-driven flippase PglK, PENTAETHYLENE GLYCOL
Authors:Perez, C, Locher, K.P.
Deposit date:2015-06-24
Release date:2015-08-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and mechanism of an active lipid-linked oligosaccharide flippase.
Nature, 524, 2015
6FN1
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BU of 6fn1 by Molmil
Zosuquidar and UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Human-mouse chimeric ABCB1 (ABCBHM), UIC2 Antigen Binding Fragment Heavy Chain, ...
Authors:Alam, A, Locher, K.P.
Deposit date:2018-02-02
Release date:2018-02-21
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6JB3
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BU of 6jb3 by Molmil
Structure of SUR1 subunit bound with repaglinide
Descriptor: ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide
Authors:Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
Deposit date:2019-01-25
Release date:2019-05-22
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019

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