4KSD

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Summary for 4KSD

Related4KSB 4KSC 4LSG
DescriptorMultidrug resistance protein 1A, R2 protein (2 entities in total)
Functional Keywordstransporter, atp binding, membrane, membrane protein, transport protein
Biological sourceMus musculus (mouse)
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Total number of polymer chains2
Total molecular weight155687.16
Authors
Primary citation
Ward, A.B.,Szewczyk, P.,Grimard, V.,Lee, C.W.,Martinez, L.,Doshi, R.,Caya, A.,Villaluz, M.,Pardon, E.,Cregger, C.,Swartz, D.J.,Falson, P.G.,Urbatsch, I.L.,Govaerts, C.,Steyaert, J.,Chang, G.
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110:13386-13391, 2013
PubMed: 23901103 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1309275110
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4.1001 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.3442000 2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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