3G61

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Summary for 3G61

Related3G5U 3G60
DescriptorMultidrug resistance protein 1a, (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (2 entities in total)
Functional Keywordsp-glycoprotein, pgp, multidrug resistance, membrane protein, cycle peptides, atp-binding, nucleotide-binding
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total molecular weight286545.46
Authors
Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G. (deposition date: 2009-02-05, release date: 2009-03-24, Last modification date: 2013-11-13)
Primary citation
Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G.
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323:1718-1722, 2009
PubMed: 19325113 (PDB entries with the same primary citation)
DOI: 10.1126/science.1168750
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.3589615.7%15.4%0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution