3G60

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Summary for 3G60

Related3G5U 3G61
DescriptorMultidrug resistance protein 1a, (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (2 entities in total)
Functional Keywordsp-glycoprotein, pgp, multidrug resistance, membrane protein, cyclic peptide
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total molecular weight285170.64
Authors
Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G. (deposition date: 2009-02-05, release date: 2009-03-24, Last modification date: 2013-11-13)
Primary citation
Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G.
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323:1718-1722, 2009
PubMed: 19325113 (PDB entries with the same primary citation)
DOI: 10.1126/science.1168750
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.3618314.3%9.6%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution